Phosphoramides, XIX [1] Phosphorus Pentoxide Amine Hydrochloride Reagents in the Synthesis of 3-Amino-l,2-benzisothiazole-l,l-dioxides and 3-Aminothieno [3,4-d] isothiazole-l,l-dioxides
نویسندگان
چکیده
3-Amino-l,2-benzisothiazole-1,1-dioxides (2b-n) have been prepared by heating saccharin (1) and the hydrochlorides of primary and secondary aliphatic amines with phosphorus pentoxide and N,N-dimethylcyclohexylamine at 240 °C. 3-Aminothieno[3,4-d]isothiazole-1,1-dioxides (6a-c) were similarly prepared from thieno[3,4-d]isothiazol3(2H)-one-1,1 -dioxide (5). 3 1 P NMR spectra were obtained of reaction mixtures and reagents. Biological screening of 2 is discussed.
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